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Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation
SummaryThe functional diversity of protein phosphatase-1 (PP1), with its countless substrates, relies on the ordered assembly of alter
Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction
The AAA protein Msp1 extracts mislocalized tail-anchored membrane proteins and targets them for degradation, thus maintaining proper c
An atomic model AAA-ATPase/20S core particle sub-complex of the 26S proteasome
Abstract The 26S proteasome is the most downstream element of the ubiquitin–proteasome pathway of protein degradation. It is co
Risk of abdominal aortic aneurysm (AAA) among male and female relatives of AAA patients.
Sex affects the presentation, treatment, and outcomes of abdominal aortic aneurysm (AAA). Although AAAs are less prevalent in women, a
The Oligomeric State of the Active Vps4 AAA ATPase
AbstractThe cellular ESCRT (endosomal sorting complexes required for transport) pathway drives membrane constriction toward the cytoso
Structure and function of the AAA+ protein CbbX, a red-type Rubisco activase
Adenosine Triphosphate, metabolism, Allosteric Regulation, drug effects, Bacterial Proteins, chemistry, genetics, ultrastructure, Ca
The Crystal Structure of the AAA Domain of the ATP-Dependent Protease FtsH of Escherichia coli a
Abstract Eubacteria and eukaryotic cellular organelles have membrane-bound ATP-dependent proteases, which degrade misassembled me
Structure of Vps4 with circular peptides and implications for translocation of two polypeptide c
Many AAA+ ATPases form hexamers that unfold protein substrates by translocating them through their central pore. Multiple structures h
Immunoreactivity of the AAA+ chaperone ClpB from Leptospira interrogans with sera from Leptospir
BACKGROUND Leptospira interrogans is a spirochaete responsible for leptospirosis in mammals. The molecular mechanisms of the Leptospir
Mechanism of Action of the Escherichia coli Phage Shock Protein PspA in Repression of the AAA Fa
The PspA protein, a negative regulator of the Escherichia coli phage shock psp operon, is produced when virulence factors are exported
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